Biochem/physiol Actions

Reversible: yes

Cell permeable: yes

General description

Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca²⁺-signaling and insulin secretion by blocking L-type Ca²⁺ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of Simvastatin, Sodium Salt (Cat. No. 567021) is also available.

Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca²⁺-signaling and insulin secretion by blocking L-type Ca²⁺ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yada, T., et al. 1999. Br. J. Pharmacol.126, 1205.Clutterbuck, R.D., et al. 1998. Br. J. Haematol.102, 522.Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol.94, 87.Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta1345, 259.Vrtovsnik, F., et al. 1997. Kidney Int.52, 1016.Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Physical form

A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Warning

Toxicity: Irritant (B)